Propamocarb
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Introduction: .Propamocarb is a specific fungicide with specific activity against several Oomycete species which cause seed, seedling, root and stem rots and foliar diseases in many edible crops and ornamental plants. The mode of of action is different compared to other Oomycete fungicides, which provides for efficacy against strains that have developed resistance to other fungicides. Crops include potatoes, turf, and ornamentals.
Common name: Propamocarb
Another name: Propamocarbe; Propyl (3-(dimethylamino)propyl)carbamate; Propamocarbe [ISO-French]; Nor-AM 39744; etc.
Chemical name: propyl 3-(dimethylamino)propylcarbamate hydrochloride
Empirical formula: C9H20N2O2
Structural formula:
Mol. Weight: 188.3 g/mol
CAS No.: 24579-73-5
Specifications
Leading Propamocarb supplier
Propamocarb 90% TC
Propamocarb 722 g/L SL
Packing:
BULK PACKING
Powder: 25kg/Bag, 25kg/Drum, 50kg/Drum etc.
Liquid: 200L/Drum, 20L/Drum, 10L/Drum etc.
SMALL PACKING
Powder: 1kg/Alu bag, 500g/Alu bag, 200g/Alu bag, 100g/Alu bag, 50g/Alu bag, 15g/Alu bag etc.
Liquid: 5L/Drum, 1L/Bottle, 500ml/Bottle, 250ml/Bottle, 100ml/Bottle, 50ml/Bottle etc.
Customerized packing label
Propamocarb FAO standard
Professional registration
HAZARDS IDENTIFICATION
Hazard statement(s)
H302 (100%): Harmful if swallowed.
Precautionary statement(s)
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P301+P312: IF SWALLOWED: call a POISON CENTER/doctor/... IF you feel unwell.
P330: Rinse mouth.
P501: Dispose of contents/container to an approved waste disposal plant.
Supplemental Hazard Statements: none.
MAMMALIAN TOXICOLOGY
Acute toxicity: 1) Acute oral LD50 for rats is >2000 mg/kg. 2) Acute dermal LD50 for rats is >2000 mg/kg. 3) Acute inhalation toxicity LC50 (4 h) for rats is >5.5 mg/L. 4) Skin irritation: Non-irritating to skin (rabbits). 5) Eye irritation: Non-irritating to eyes (rabbits). 6) Skin sensitization for guinea pig: Not sensitizing in guinea-pigs (Buehler).
NOEL: (2 y) for rats is 84 mg/kg/day; (18 m) for mice is 106 mg/kg/day; (1 y) for dogs is 39 mg/kg/day. Other Not carcinogenic. Not genotoxic.
ADI (JMPR) 0-0.4 mg/kg b.w. [2005]
Classification:
WHO Classification: U (Unlikely to present an acute hazard)
EC Risk Classification: Xn - Harmful: R22
US EPA Classification (formulation): Not available
ECOTOXICOLOGY
Effect on fish: Acute LC50 (96 h) for Sheepshead minnow is 96.8 mg/l. Effects on aquatic invertebrates: Acute EC50 (48 h) for Daphnia magna is 106 mg/l. Effects on algae: Acute 72 hour EC50 for Scenedesmus quadricauda is 301 mg/l. Effects on bees: contact acute 48 hour LD50 is >100 g/bee, oral acute 48 hour LD50 is >84 g/bee.
ENVIRONMENTAL FATE
Animals Rapidly absorbed and almost totally excreted (>90% in 24 h), mainly via urine. Mineralisation occurs via oxidation and hydrolytic decomposition. Plants Mainly unchanged in plants. Soil/Environment Rapidly degraded in soil by microbial processes, following a brief lag phase, DT50 <30 d, DT90 <70 d. Propamocarb hydrochloride is retained in the upper soil layer (4-20 cm) and little is found in leachate. Stable in aqueous medium, but rapidly degraded by aquatic micro-organisms (up to 97% in 35 d). It is adsorbed onto sediment, but with limited desorption.
Usage: Propamocarb was distributed by Bayer CropScience. It is fungicide for specific control of Phycomycetes and effective against Phytophthora spp. and Pythium spp. Normally used as the hydrochloride salt.
Application: Biochemistry Reduces mycelial growth and development of sporangia and (zoo)spores; influences the biochemical synthesis of membranes. Mode of action Systemic fungicide with protective action. Absorbed by the roots and leaves, and transported acropetally. Propamocarb is a systemic fungicide used for control of soil, root and leaf disease caused by oomycetes. It is used by watering or spraying. Propamocarb is absorbed and distributed through the plant's tissue.
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