Introduction: Carbendazim is a widely used, broad-spectrum benzimidazole fungicide and a metabolite of benomyl. It is also employed as a casting worm control agent in amenity turf situations such as golf greens, tennis courts etc. and in some countries is licensed for that use only.
Common name: Carbendazim
Another name: Mercarzole; Carbendazole
Chemical Name: methyl benzimidazol-2-ylcarbamate
Empirical formula: C9H9N3O2
Mol. Weight: 191.2
CAS No.: 10605-21-7
Leading Carbendazim supplier
98% Carbendazim TC,
50% Carbendazim WP,
500 g/L Carbendazim SC,
carbendazim 25%+diethofencarb 25% WP
Customerized Packing label
Packing: Required by customer
Carbendazim FAO standard
HAZARDS IDENTIFICATION: Possible risk of irreversible effects.
Product analysis by u.v. spectrophotometry or hplc (CIPAC Handbook, 1998, H, 61). Residues in crops determined using methods for benomyl, hplc (J. J. Kirkland et al., J. Agric. Food Chem., 1973, 21, 368; Pestic. Anal. Man., 1979, II; J. E. Farrow et al., Analyst (London), 1977, 102, 752) or fluorimetry or colorimetry of derivatives (H. L. Pease & J. A. Gardiner, J. Agric. Food Chem., 1969, 17, 267; N. Aharonson & A. Ben-Aziz, J. Assoc. Off. Anal. Chem., 1973, 56, 1330).
Reviews 74, 76 Oral Acute oral LD50 for rats 6400, dogs >2500 mg/kg. Skin and eye Acute percutaneous LD50 for rabbits >10 000, rats >2000 mg/kg. Non-irritating to skin and eyes (rabbits). Not a skin sensitiser (guinea pigs). Inhalation LC50 (4 h) for rats, rabbits, guinea pigs or cats, no effect with suspension (10 g/l water). NOEL (2 y) for dogs 300 mg/kg diet, corresponding to 6-7 mg/kg b.w. ADI (JMPR) 0.03 mg/kg b.w. . Other Acute i.p. LD50 for male rats 7320, female rats 15 000 mg/kg. Toxicity class WHO (a.i.) U EC classification R68
Birds Acute oral LD50 for quail 5826-15 595 mg/kg. Fish LC50 (96 h) for carp 0.61, rainbow trout 0.83, bluegill sunfish >17.25, guppy >8 mg/l. Daphnia LC50 (48 h) 0.13-0.22 mg/l. Algae EC50 (72 h) for Scenedesmus subspicatus 419, Selenastrum capricornutum 1.3 mg/l. Bees LD50 (contact) >50 mg/bee. Worms LC50 (4 w) for Eisenia foetida 6 mg/kg soil.
EHC 149 (WHO, 1993). EHC 149 concludes that, although highly toxic to aquatic organisms, low bioavailability in surface waters makes it unlikely this toxicity will occur in the field. Animals In male rats, following a single oral administration of 3 mg/kg, 66% was eliminated in the urine within 6 hours. Plants Readily absorbed by plants. One degradation product is 2-aminobenzimidazole. Soil/Environment 2-Aminobenzimidazole has been found as a minor metabolite. DT50 in soil 8-32 d under outdoor conditions. Carbendazim decomposes in the environment, DT50 6-12 mo on bare soil, 3-6 mo on turf, and 2-25 mo in water under aerobic and anaerobic conditions, respectively. It is mainly decomposed by micro-organisms. Koc 200-250.
Usage: The fungicide is used to control plant diseases in cereals and fruits, including citrus, bananas, strawberries, pineapples, and pomes. It is also controversially used in Queensland, Australia on macadamia plantations.A 4.7% solution of carbendazim hydrochloride, sold as Eertavas, is marketed as a treatment for Dutch elm disease.
Biochemistry Inhibits beta-tubulin synthesis. Mode of action Systemic fungicide with protective and curative action. Absorbed through the roots and green tissues, with translocation acropetally. Acts by inhibiting development of the germ tubes, the formation of appressoria, and the growth of mycelia. Uses Control of Septoria, Fusarium, Erysiphe and Pseudocercosporella in cereals; Sclerotinia, Alternaria and Cylindrosporium in oilseed rape; Cercospora and Erysiphe in sugar beet; Uncinula and Botrytis in grapes; Cladosporium and Botrytis in tomatoes; Venturia and Podosphaera in pome fruit and Monilia and Sclerotinia in stone fruit. Application rates vary from 120-600 g/ha, depending on crop. A seed treatment (0.6-0.8 g/kg) will control Tilletia, Ustilago, Fusarium and Septoria in cereals, and Rhizoctonia in cotton. Also shows activity against storage diseases of fruit as a dip (0.3-0.5 g/l).