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Name Of Product CAS NO. Specification MSDS
Nicosulfuron 111991-09-4 95%TC,75%WDG&WP 4%OD&SC
 

 

Nicosulfuron 烟嘧磺隆, 烟磺隆

 

Introduction: Nicosulfuron is a member of the sulfonylurea family of herbicides. It controls weeds by inhibiting the plant enzyme acetolactate synthase, or ALS. This enzyme is not found in livestock, fish or man. Inhibiting the ALS enzyme system blocks the production of the amino acids, valine and isoleucine, essential building blocks of proteins and other plant components.

Common name: Nicosulfuron
Chemical Name:  2-(4,6-dimethoxypyrimidin-2-ylcarbamoylsulfamoyl)-N,N-dimethylnicotinamide; 1-(4,6-dimethoxypyrimidin-2-yl)-3-(3-dimethylcarbamoyl-2-pyridylsulfonyl)urea
Empirical formula:  C15H18N6O6S
Structural formula:
   
  
Mol. Weight: 410.4
CAS No.: 111991-09-4

 

Specifications
Leading Nicosulfuron supplier
Nicosulfuron 97% TC
Nicosulfuron 75% WDG
Nicosulfuron 75% WP
Nicosulfuron 4%  SC
Nicosulfuron 4%  OD

 

Customerized Packing label
Packing: Required by customer
Nicosulfuron FAO standard
Professional registration

 

HAZARDS IDENTIFICATION:
Ingestion:May be harmful if swallowed.
Inhalation: May be harmful if inhaled.Material may be irritating to mucous membranes and upper respiratory tract.
Skin: Causes skin irritation.May be harmful if absorbed through the skin.
Eyes: Causes irritation.
Hazards: Emits toxic fumes under fire condition.

 

Usage: Selective post-emergence control in maize of annual grass weeds including Setaria, Echinochloa, Digitaria, Panicum, Lolium, and Avena spp., broad-leaved weeds including Amaranthus spp. and Cruciferae, and perennials such as Sorghum halepense and Agropyron repens.

 

Application: Biochemistry Branched chain amino acid synthesis (ALS or AHAS) inhibitor. Acts by inhibiting biosynthesis of the essential amino acids valine and isoleucine, hence stopping cell division and plant growth. Maize selectivity derives from selective metabolism (P450-mediated pyrimidine-5-hydroxylation, followed by conjugation with glucose). Mode of action Selective systemic herbicide, absorbed by the foliage and roots, with rapid translocation in xylem and phloem to the meristematic tissues. Uses Selective post-emergence control in maize of annual grass weeds including Setaria, Echinochloa, Digitaria, Panicum, Lolium, and Avena spp., broad-leaved weeds including Amaranthus spp. and Cruciferae, and perennials such as Sorghum halepense and Agropyron repens. Applied at 35-70 g/ha. Formulation types SC; WG. Selected products: 'Accent' (DuPont); 'Dasul' (Ishihara Sangyo, Syngenta); 'Milagro' (France) (Ishihara Sangyo, Syngenta)

 

ANALYSIS
Product by hplc. Methods for sulfonylurea residues in crops, soil and water reviewed (A. C. Barefoot et al., Proc. Br. Crop Prot. Conf. - Weeds, 1995, 2, 707). Details from Ishihara Sangyo.

 

MAMMALIAN TOXICOLOGY
Oral Acute oral LD50 for male and female rats and mice >5000 mg/kg. Skin and eye Acute percutaneous LD50 for male and female rats >2000 mg/kg. Moderate eye irritant; not a skin irritant (rabbits); not a skin sensitiser (guinea pigs). The 75% formulation is not an eye irritant. Inhalation LC50 for rats (4 h) 5.47 mg/l. NOEL In 28 d feeding trials on rats and mice, no adverse effect up to 30 g/kg diet. Other Non-mutagenic in the Ames test. Toxicity class WHO (a.i.) U; EPA (formulation) IV

 


ECOTOXICOLOGY
Birds Dietary oral LD50 for bobwhite quail >2250 mg/kg. Dietary LC50 for mallard ducks and bobwhite quail >5620 ppm. Fish LC50 (96 h) for bluegill sunfish and rainbow trout >1000 mg/l. Daphnia LC50 (48 h) >1000 mg/l. Algae NOEC (96 h) for green algae 100 mg/l. Bees LD50 (contact) >20 mg/bee; dietary LC50 (48 h) >1000 ppm. NOEC 500 ppm. Worms LC50 (14 d) for earthworms >1000 mg/kg.


ENVIRONMENTAL FATE
Animals In goats, following a dose of 60 ppm, <0.1 ppm was found in tissues and milk; therefore nicosulfuron and its metabolites do not bioaccumulate. Hydrolysis of the sulfonylurea bridge and hydroxylation were the main metabolic pathways. Plants Degraded rapidly in maize, DT50 1.5-4.5 d. Residues <0.02 ppm in all crops. Hydrolysis of the sulfonylurea bridge to form the pyridine sulfonamide and pyrimidine amine, and hydroxylation on the pyrimidine ring, were the main metabolic pathways. Soil/Environment Soil DT50 (aerobic) 26 d (pH 6.1, 5.1% o.m., 25 °C). In four sandy loams, Kd (25 °C) 0.16 (pH 6.6, 1.1% o.m.) to 1.73 (pH 5.4, 4.3% o.m.). Photolysis DT50 (soil) 60-67 d; (water) 14-19 d (pH 5), 200-250 d (pH 7), 180-200 d (pH 9). Values from separate studies were: Soil DT50 24-43 d (20 °C); DT90 80-143 d (20 °C). Kd 0.05-0.7. In water, DT50 15 d (pH 5, 20 °C).

 

 

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